Senior Scientist (Chemistry/Chemical Biology) at CS Genetics
Cambridge, GB

CS Genetics is developing pathbreaking new technology for genomics, based on foundational scientific insights and sophisticated conceptual innovations in NGS techniques. Our work will accelerate basic biologic research and enable lifesaving new clinical diagnostics. We have an extremely skilled team, a large global intellectual property estate, and amongst the most inventive, ambitious technology roadmaps in life science.

We’re developing a radically-new, instrument-free platform for single-cell sequencing with disruptive throughput and experimental ease. We’re growing our Cambridge R&D team to help launch a new era of NGS-based cellular analysis.

Position Summary

We’re looking for an exceptional, experienced, and audacious laboratory scientist to join our NGS R&D team as a Senior Scientist (Chemistry/Chemical Biology). The ideal candidate will have a convincing track-record of developing, using and/or refining complex technologies/assays for measurement/detection of nucleic acids and/or proteins, especially within the NGS field; they will have comprehensive knowledge of molecular methods and tools for processing, modification, and detection of nucleic acids; they will be a rigorous, analytical, and organised experimentalist; they will have a keen intellectual interest in DNA sequencing technologies and their applications; they will have a keen personal interest in saving and extending lives through life science R&D.

Key Responsibilities

 

  • Develop, assess, and optimise categorically new laboratory techniques and assay workflows for NGS
  • Engineer and evaluate new types of macromolecular and/or solid-phase consumable reagents
  • Work with a team of other scientists developing new NGS technologies for research and medicine
  • Coordinate complex R&D roadmaps to prioritise, track, and achieve key technical milestones therein
  • Conceive and perform systematic evaluation/optimisation processes for NGS reagents and workflows
  • Communicate internally and with external partners via oral updates, written reports, and technical meetings

 

Required Skills and Background

  • PhD/DPhil in chemistry, chemical biology, biochemistry or similar relevant subject
  • 3+ years post-PhD experience as a laboratory scientist in academia and/or industry
  • Comprehensive knowledge and experience in one or more of the following areas:
    • Nucleic acid chemistry
    • Bioconjugation
    • Biophysics
    • Surface chemistry
    • Formulation chemistry
  • Significant hands-on experience with nucleic acid techniques (e.g. modification and conjugation of oligonucleotides, detection and assay development with spectroscopic techniques like UV and fluorescence, surface chemistries used for nucleic acid technologies, etc.)
  • Understanding of NGS sequencing platforms and familiarity with the chemistry/physics/biology interface
  • Enthusiasm for a demanding, fast-paced R&D role in a small-startup environment

Desired Skills and Background

  • Experience performing sophisticated NGS research and technology development
  • Experience with common molecular biology techniques (e.g. PCR/qPCR, RT, electrophoresis, etc.)
  • Experience developing/refining sophisticated nucleic acid or protein detection technologies/methods (molecular, optical, or otherwise)
  • Broad scientific knowledgebase relevant to nucleic acids and NGS
  • Peer-reviewed publications and/or patent applications in chemistry, chemical biology, nucleic acids, genomics/NGS, or similar
  • Knowledge of formal Design of Experiments (DoE) methodologies in NGS R&D